Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.248


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_311381800.301.1e-01Click!
SOX2chr3_+_181429711-0.202.9e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216241321 17.347 FN1
fibronectin 1
chr8_+_39771327 8.002 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr16_-_55867016 7.403 NM_001025194
NM_001025195
NM_001266
 CES1


carboxylesterase 1


chr3_+_133494275 4.072 TF
transferrin
chr12_-_91573264 3.691 NM_133503
 DCN
decorin
chr3_-_195310985 2.799 NM_001647
 APOD
apolipoprotein D
chr7_+_80267972 2.590 CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80267922 2.237 CD36
CD36 molecule (thrombospondin receptor)
chr3_-_195310770 2.233 APOD
apolipoprotein D
chr4_-_159093523 1.853 FAM198B
family with sequence similarity 198, member B
chr16_-_21314371 1.536 NM_001014444
NM_001888
 CRYM

crystallin, mu

chr17_+_3379295 1.522 NM_000049
 ASPA
aspartoacylase
chr11_+_69455938 1.512 CCND1
cyclin D1
chr7_-_16505292 1.465 NM_015464
 SOSTDC1
sclerostin domain containing 1
chr6_+_32407618 1.420 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_+_111126706 1.383 NM_198498
 C11orf53
chromosome 11 open reading frame 53
chr7_+_89843133 1.366 NM_001040666
 STEAP2
STEAP family member 2, metalloreductase
chr11_+_69455978 1.335 CCND1
cyclin D1
chr4_-_110723334 1.297 NM_000204
 CFI
complement factor I
chr10_+_123754141 1.231 TACC2
transforming, acidic coiled-coil containing protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
13.30 3.43e-02 GO:0043252 sodium-independent organic anion transport
11.97 9.92e-03 GO:0015721 bile acid and bile salt transport
9.58 4.31e-02 GO:0072378 blood coagulation, fibrin clot formation
7.77 2.74e-03 GO:0008206 bile acid metabolic process
6.28 6.07e-04 GO:0072376 protein activation cascade
5.15 3.69e-02 GO:0015718 monocarboxylic acid transport
4.14 1.30e-03 GO:0007156 homophilic cell adhesion
2.92 3.49e-02 GO:0008202 steroid metabolic process
2.75 1.48e-02 GO:0016337 cell-cell adhesion
2.72 1.18e-02 GO:0032787 monocarboxylic acid metabolic process
2.49 1.85e-06 GO:0006955 immune response
2.35 2.65e-02 GO:0002684 positive regulation of immune system process
2.33 3.19e-02 GO:0050776 regulation of immune response
2.13 6.85e-03 GO:0002682 regulation of immune system process
2.06 9.65e-03 GO:0007155 cell adhesion
2.06 9.65e-03 GO:0022610 biological adhesion
2.01 3.32e-05 GO:0002376 immune system process
2.00 3.61e-03 GO:0009611 response to wounding
1.99 1.39e-02 GO:0006952 defense response
1.97 2.16e-02 GO:0048584 positive regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.23 1.47e-05 GO:0005615 extracellular space
2.01 3.90e-05 GO:0044421 extracellular region part
1.83 6.87e-08 GO:0005576 extracellular region
1.68 1.19e-02 GO:0005887 integral to plasma membrane
1.65 2.03e-02 GO:0031226 intrinsic to plasma membrane
1.55 1.39e-03 GO:0044459 plasma membrane part
1.39 2.81e-04 GO:0071944 cell periphery
1.39 2.86e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
23.94 4.55e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity