Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.248


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_311381800.301.1e-01Click!
SOX2chr3_+_181429711-0.202.9e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216241321 17.347 FN1
fibronectin 1
chr8_+_39771327 8.002 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr16_-_55867016 7.403 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr3_+_133494275 4.072 TF
transferrin
chr12_-_91573264 3.691 NM_133503
DCN
decorin
chr3_-_195310985 2.799 NM_001647
APOD
apolipoprotein D
chr7_+_80267972 2.590 CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80267922 2.237 CD36
CD36 molecule (thrombospondin receptor)
chr3_-_195310770 2.233 APOD
apolipoprotein D
chr4_-_159093523 1.853 FAM198B
family with sequence similarity 198, member B
chr16_-_21314371 1.536 NM_001014444
NM_001888
CRYM

crystallin, mu

chr17_+_3379295 1.522 NM_000049
ASPA
aspartoacylase
chr11_+_69455938 1.512 CCND1
cyclin D1
chr7_-_16505292 1.465 NM_015464
SOSTDC1
sclerostin domain containing 1
chr6_+_32407618 1.420 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_+_111126706 1.383 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr7_+_89843133 1.366 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr11_+_69455978 1.335 CCND1
cyclin D1
chr4_-_110723334 1.297 NM_000204
CFI
complement factor I
chr10_+_123754141 1.231 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_37723378 1.189


chrY_-_2655478 1.189 NM_003140
SRY
sex determining region Y
chrX_+_7137471 1.168 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr1_-_177133950 1.108 NM_004319
NM_207108
ASTN1

astrotactin 1

chr2_+_207406815 1.087 ADAM23
ADAM metallopeptidase domain 23
chr17_+_3377346 1.060 NM_001128085
ASPA
aspartoacylase
chr5_+_140782367 0.863 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr2_-_161056573 0.861 NM_000888
ITGB6
integrin, beta 6
chr5_+_173472692 0.850 NM_015980
HMP19
HMP19 protein
chr11_+_69455837 0.824 NM_053056
CCND1
cyclin D1
chr7_+_80267782 0.821 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr2_+_87755059 0.821 LINC00152
long intergenic non-protein coding RNA 152
chr10_+_123923104 0.819 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr2_-_175712276 0.796 NM_001206602
CHN1
chimerin (chimaerin) 1
chr10_+_7745284 0.783 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_75193297 0.774 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr17_-_79105747 0.771 NM_004920
AATK
apoptosis-associated tyrosine kinase
chr9_-_74675498 0.769 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr1_-_116383692 0.725 NM_005599
NHLH2
nescient helix loop helix 2
chr11_+_5710926 0.716 TRIM22
tripartite motif containing 22
chr1_-_93399531 0.690


chr7_-_139763520 0.680 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr11_-_35441501 0.668 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr15_+_59904090 0.665 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_+_69455884 0.659 CCND1
cyclin D1
chr2_+_204801453 0.658 NM_012092
ICOS
inducible T-cell co-stimulator
chr9_-_140196702 0.648 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr2_-_215896809 0.646 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chrX_+_2958274 0.639 NM_001201538
ARSF
arylsulfatase F
chrX_+_72667089 0.631 NM_005193
CDX4
caudal type homeobox 4
chr1_-_1711453 0.625 NM_001198994
NADK
NAD kinase
chrM_-_9203 0.625


chrM_+_8857 0.620


chr9_-_75567915 0.608 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr7_+_1126442 0.606 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr3_-_42917191 0.604 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_-_161056762 0.594 ITGB6
integrin, beta 6
chr5_+_76114881 0.588 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr9_+_105757592 0.583 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr13_-_99959649 0.581 NM_004951
GPR183
G protein-coupled receptor 183
chr6_-_76782204 0.577 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr16_+_72088507 0.576 NM_001126102
NM_005143
HP

haptoglobin

chr9_+_99691285 0.569 NM_001045477
NM_001170741
FAM22G

family with sequence similarity 22, member G

chr12_+_20963637 0.567 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr20_-_44718564 0.563 NM_020967
NCOA5
nuclear receptor coactivator 5
chr13_-_28543143 0.560 CDX2
caudal type homeobox 2
chrX_+_135383121 0.557 NM_153834
GPR112
G protein-coupled receptor 112
chrX_-_124097601 0.543 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chrM_+_9182 0.543


chr12_-_123187842 0.542 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr10_+_7745325 0.535 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_-_33465191 0.530 NOL6
nucleolar protein family 6 (RNA-associated)
chr12_+_85430098 0.525 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr11_+_5710816 0.523 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr18_+_63417487 0.521 NM_033646
CDH7
cadherin 7, type 2
chr10_+_118305427 0.518 NM_000936
PNLIP
pancreatic lipase
chr4_+_100495972 0.517 MTTP
microsomal triglyceride transfer protein
chr13_-_28543290 0.516 NM_001265
CDX2
caudal type homeobox 2
chrM_+_9217 0.515


chrX_+_111119278 0.510 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr5_+_140207562 0.507 NM_018909
NM_031848
NM_031849
PCDHA6


protocadherin alpha 6


chr7_+_142560512 0.505 EPHB6
EPH receptor B6
chr2_-_45795104 0.501 SRBD1
S1 RNA binding domain 1
chr1_-_150552077 0.498 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr20_-_55100980 0.486 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr5_+_140254930 0.478 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr4_+_100432160 0.476 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr20_-_44718545 0.475 NCOA5
nuclear receptor coactivator 5
chr2_+_113885145 0.472 IL1RN
interleukin 1 receptor antagonist
chr7_+_129015483 0.470 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_+_113885137 0.464 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr1_+_50574601 0.458 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_11091805 0.452 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr5_-_95158465 0.450 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr6_+_152128453 0.450 NM_001122740
ESR1
estrogen receptor 1
chr11_-_59633942 0.447 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr2_-_75062214 0.439


chr5_+_42565963 0.438 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr16_+_57050985 0.437 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr12_-_47473424 0.437 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr6_-_32497925 0.425 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr8_+_32579350 0.415 NM_001159996
NRG1
neuregulin 1
chr6_+_64286348 0.411 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr17_-_46608271 0.407 NM_002144
HOXB1
homeobox B1
chr10_+_5005685 0.405 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_+_87754991 0.404 LINC00152
long intergenic non-protein coding RNA 152
chr12_-_123201319 0.402 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr4_-_15940362 0.401 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr1_+_61542790 0.397


chr5_+_76114832 0.396 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr4_-_159094163 0.386 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr1_+_87012758 0.385 NM_012128
CLCA4
chloride channel accessory 4
chr5_+_173472737 0.381 HMP19
HMP19 protein
chr1_-_89591685 0.370 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_162466963 0.369 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr20_+_18794369 0.366 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr11_+_70194385 0.364 PPFIA1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr15_+_25068793 0.362 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr18_+_63418156 0.349 NM_004361
CDH7
cadherin 7, type 2
chr5_+_40841296 0.348 NM_032587
CARD6
caspase recruitment domain family, member 6
chr12_-_102874373 0.348 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr3_-_42305438 0.346 NM_001174138
CCK
cholecystokinin
chr10_+_5005601 0.345 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_-_49229994 0.339 NM_001014986
NM_001193471
NM_001193472
NM_001193473
NM_004476
FOLH1




folate hydrolase (prostate-specific membrane antigen) 1




chr5_-_94417544 0.337 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr12_-_14996381 0.328 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr20_-_6104056 0.324 NM_017671
FERMT1
fermitin family member 1
chr6_-_31560497 0.317 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr11_-_128457452 0.316 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr1_-_163113938 0.315 RGS5
regulator of G-protein signaling 5
chr5_+_72469022 0.313 NM_153217
TMEM174
transmembrane protein 174
chr1_+_162602198 0.309 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr9_-_21142143 0.308 NM_002177
IFNW1
interferon, omega 1
chr15_+_59903980 0.306 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr2_+_74120092 0.306 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr15_+_25101697 0.305 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_+_140247767 0.305 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr4_-_156787377 0.304 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr2_+_36923832 0.303 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr10_+_7745354 0.302 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745229 0.302 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_33359607 0.297 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr5_-_95158365 0.297 GLRX
glutaredoxin (thioltransferase)
chr7_+_55433140 0.296 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr5_+_140235594 0.295 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr12_-_102874321 0.294 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_-_57026540 0.294 NM_005372
MOS
v-mos Moloney murine sarcoma viral oncogene homolog
chr9_-_97090903 0.293 NM_017561
FAM22F
family with sequence similarity 22, member F
chr19_+_42259397 0.291 NM_002483
CEACAM6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
chr2_+_74120132 0.290 ACTG2
actin, gamma 2, smooth muscle, enteric
chr10_+_123922940 0.287 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_+_167525294 0.286 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr8_+_19796581 0.286 NM_000237
LPL
lipoprotein lipase
chr10_+_5005453 0.285 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr5_-_147162175 0.284 JAKMIP2
janus kinase and microtubule interacting protein 2
chr6_+_24357130 0.282 NM_181337
KAAG1
kidney associated antigen 1
chr4_-_100815666 0.278 NM_001243736
NM_021970
LAMTOR3

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

chr12_-_130646767 0.278 FLJ31485
uncharacterized LOC440119
chr20_+_68312 0.275 NM_153325
DEFB125
defensin, beta 125
chr14_+_39703119 0.274 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_+_68592317 0.272 NM_002664
PLEK
pleckstrin
chr16_+_76311175 0.271 NM_033401
CNTNAP4
contactin associated protein-like 4
chr10_+_7745341 0.270 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_29577989 0.270 NM_032517
LYZL1
lysozyme-like 1
chr1_-_177133818 0.269 ASTN1
astrotactin 1
chr5_-_64777703 0.269 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr15_+_67458492 0.267 NM_001145104
SMAD3
SMAD family member 3
chr12_-_105322056 0.267 NM_032148
SLC41A2
solute carrier family 41, member 2
chr9_-_104145800 0.267 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chrX_+_91090459 0.264 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr18_+_29027731 0.261 NM_001944
DSG3
desmoglein 3
chr2_-_171923482 0.257 NM_001136555
TLK1
tousled-like kinase 1
chr17_+_32582295 0.256 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr2_-_2334887 0.252 NM_015025
MYT1L
myelin transcription factor 1-like
chr14_-_101036130 0.252 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr17_-_40190043 0.251 NM_001242704
ZNF385C
zinc finger protein 385C
chr6_-_89927495 0.249 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr5_-_997408 0.249 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr20_-_31592231 0.249 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr2_+_234600320 0.249 NM_205862
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_128928040 0.247 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_123300120 0.246 NM_139243
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chr12_-_6484389 0.245 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_-_21487831 0.245 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr2_-_233641225 0.244 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr10_-_46030798 0.244 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr12_-_102874299 0.242 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_41540187 0.240 LIMCH1
LIM and calponin homology domains 1
chr22_+_35695267 0.240 NM_001135729
TOM1
target of myb1 (chicken)
chrX_-_49965003 0.239 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr5_-_9630462 0.238 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr22_+_18043147 0.235 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr5_+_140771482 0.234 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr9_-_114545772 0.233 NM_173521
C9orf84
chromosome 9 open reading frame 84
chr4_-_159093717 0.231 NM_016613
FAM198B
family with sequence similarity 198, member B
chr1_+_32050510 0.230 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_-_32827843 0.230 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr14_-_106967080 0.229 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_122085475 0.228 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr6_-_13295817 0.226 NM_001242698
LOC100130357
uncharacterized LOC100130357

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.49 1.85e-06 GO:0006955 immune response
2.01 3.32e-05 GO:0002376 immune system process
6.28 6.07e-04 GO:0072376 protein activation cascade
4.14 1.30e-03 GO:0007156 homophilic cell adhesion
1.30 2.56e-03 GO:0050896 response to stimulus
7.77 2.74e-03 GO:0008206 bile acid metabolic process
2.00 3.61e-03 GO:0009611 response to wounding
1.63 6.41e-03 GO:0048583 regulation of response to stimulus
1.32 6.78e-03 GO:0032501 multicellular organismal process
2.13 6.85e-03 GO:0002682 regulation of immune system process
2.06 9.65e-03 GO:0007155 cell adhesion
2.06 9.65e-03 GO:0022610 biological adhesion
11.97 9.92e-03 GO:0015721 bile acid and bile salt transport
2.72 1.18e-02 GO:0032787 monocarboxylic acid metabolic process
1.99 1.39e-02 GO:0006952 defense response
2.75 1.48e-02 GO:0016337 cell-cell adhesion
1.39 1.75e-02 GO:0023052 signaling
1.97 2.16e-02 GO:0048584 positive regulation of response to stimulus
2.35 2.65e-02 GO:0002684 positive regulation of immune system process
1.60 2.68e-02 GO:0007166 cell surface receptor linked signaling pathway
2.33 3.19e-02 GO:0050776 regulation of immune response
13.30 3.43e-02 GO:0043252 sodium-independent organic anion transport
2.92 3.49e-02 GO:0008202 steroid metabolic process
5.15 3.69e-02 GO:0015718 monocarboxylic acid transport
9.58 4.31e-02 GO:0072378 blood coagulation, fibrin clot formation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.83 6.87e-08 GO:0005576 extracellular region
2.23 1.47e-05 GO:0005615 extracellular space
2.01 3.90e-05 GO:0044421 extracellular region part
1.39 2.81e-04 GO:0071944 cell periphery
1.39 2.86e-04 GO:0005886 plasma membrane
1.55 1.39e-03 GO:0044459 plasma membrane part
1.68 1.19e-02 GO:0005887 integral to plasma membrane
1.65 2.03e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
23.94 4.55e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity